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Age-related expression of SARS-CoV-2 priming protease TMPRSS2 in the developing lung

Bryce A. Schuler, A. Christian Habermann, Erin J. Plosa, Chase J. Taylor, Christopher Jetter, Meghan E. Kapp, John T. Benjamin, Peter Gulleman, David S. Nichols, Lior Z. Braunstein, View ORCID ProfileMichael Koval, Susan H. Guttentag, Timothy S. Blackwell, Vanderbilt COVID-19 Consortium Cohort, Steven A. Webber, Nicholas E. Banovich, View ORCID ProfileJonathan A. Kropski, Jennifer M. S. Sucre, HCA Lung Biological Network
doi: https://doi.org/10.1101/2020.05.22.111187
Bryce A. Schuler
1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
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A. Christian Habermann
2Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
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Erin J. Plosa
3Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
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Chase J. Taylor
2Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
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Christopher Jetter
3Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
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Meghan E. Kapp
4Department Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN
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John T. Benjamin
3Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
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Peter Gulleman
3Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
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David S. Nichols
2Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
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Lior Z. Braunstein
5Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York
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Michael Koval
6Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, GA
7Department of Cell Biology, Emory University, Atlanta, GA
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  • ORCID record for Michael Koval
Susan H. Guttentag
3Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
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Timothy S. Blackwell
2Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
8Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN
9Department of Veterans Affairs Medical Center, Nashville, TN
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10Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
Steven A. Webber
1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
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Nicholas E. Banovich
11Translational Genomics Research Institute, Phoenix, AZ
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Jonathan A. Kropski
2Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
8Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN
9Department of Veterans Affairs Medical Center, Nashville, TN
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  • ORCID record for Jonathan A. Kropski
  • For correspondence: jennifer.sucre{at}vumc.org jon.kropski{at}vumc.org
Jennifer M. S. Sucre
3Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
8Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN
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  • For correspondence: jennifer.sucre{at}vumc.org jon.kropski{at}vumc.org
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Article Information

doi 
https://doi.org/10.1101/2020.05.22.111187
History 
  • May 23, 2020.

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  • You are currently viewing Version 1 of this article (May 23, 2020 - 22:18).
  • View Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Bryce A. Schuler1,
  2. A. Christian Habermann2,
  3. Erin J. Plosa3,
  4. Chase J. Taylor2,
  5. Christopher Jetter3,
  6. Meghan E. Kapp4,
  7. John T. Benjamin3,
  8. Peter Gulleman3,
  9. David S. Nichols2,
  10. Lior Z. Braunstein5,
  11. Michael Koval6,7,
  12. Susan H. Guttentag3,
  13. Timothy S. Blackwell2,8,9,
  14. Vanderbilt COVID-19 Consortium Cohort10,
  15. Steven A. Webber1,
  16. Nicholas E. Banovich11,
  17. Jonathan A. Kropski2,8,9,*,†,
  18. Jennifer M. S. Sucre3,8,*,†,
  19. HCA Lung Biological Network
  1. 1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
  2. 2Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
  3. 3Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
  4. 4Department Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN
  5. 5Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York
  6. 6Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, GA
  7. 7Department of Cell Biology, Emory University, Atlanta, GA
  8. 8Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN
  9. 9Department of Veterans Affairs Medical Center, Nashville, TN
  10. 10Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
  11. 11Translational Genomics Research Institute, Phoenix, AZ
  1. ↵†Address correspondence to: Jennifer M. S. Sucre (jennifer.sucre{at}vumc.org) or Jonathan A. Kropski (jon.kropski{at}vumc.org)
  1. ↵* Equal contribution

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Age-related expression of SARS-CoV-2 priming protease TMPRSS2 in the developing lung
Bryce A. Schuler, A. Christian Habermann, Erin J. Plosa, Chase J. Taylor, Christopher Jetter, Meghan E. Kapp, John T. Benjamin, Peter Gulleman, David S. Nichols, Lior Z. Braunstein, Michael Koval, Susan H. Guttentag, Timothy S. Blackwell, Vanderbilt COVID-19 Consortium Cohort, Steven A. Webber, Nicholas E. Banovich, Jonathan A. Kropski, Jennifer M. S. Sucre, HCA Lung Biological Network
bioRxiv 2020.05.22.111187; doi: https://doi.org/10.1101/2020.05.22.111187
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Age-related expression of SARS-CoV-2 priming protease TMPRSS2 in the developing lung
Bryce A. Schuler, A. Christian Habermann, Erin J. Plosa, Chase J. Taylor, Christopher Jetter, Meghan E. Kapp, John T. Benjamin, Peter Gulleman, David S. Nichols, Lior Z. Braunstein, Michael Koval, Susan H. Guttentag, Timothy S. Blackwell, Vanderbilt COVID-19 Consortium Cohort, Steven A. Webber, Nicholas E. Banovich, Jonathan A. Kropski, Jennifer M. S. Sucre, HCA Lung Biological Network
bioRxiv 2020.05.22.111187; doi: https://doi.org/10.1101/2020.05.22.111187

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