Jain, Neha M.Culley, AlisonKnoop, TeresaMicheel, ChristineOsterman, TravisLevy, Mia2020-05-022020-05-022019-06-21DOI: 10.1200/CCI.19.00033 JCO Clinical Cancer Informatics - published online June 21, 2019 PMID: 312259832473-4276http://hdl.handle.net/1803/9999In this work, we present a conceptual framework to support clinical trial optimization and enrollment workflows and review the current state, limitations, and future trends in this space. This framework includes knowledge representation of clinical trials, clinical trial optimization, clinical trial design, enrollment workflows for prospective clinical trial matching, waitlist management, and, finally, evaluation strategies for assessing improvement. (C) 2019 by American Society of Clinical Oncologyen-USClin Cancer Inform. © 2019 by American Society of Clinical Oncology Licensed under the Creative Commons Attribution 4.0 LicenseArticle10.1200/CCI.19.00033