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. 2024 Jul 4;134(17):e179238.
doi: 10.1172/JCI179238.

Relationship between maternal serotonin levels and autism-associated genetic variants

Amandeep Jutla  1   2 , Lauren C Shuffrey  3 , Stephen J Guter  4 , Kally C O'Reilly  1   2 , George M Anderson  5 , James S Sutcliffe  6 , Edwin H Cook  4 , Jeremy Veenstra-VanderWeele  1   2
Affiliations

Relationship between maternal serotonin levels and autism-associated genetic variants

Amandeep Jutla et al. J Clin Invest. .
No abstract available

Keywords: Genetic variation; Neuroscience.

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Conflict of interest statement

Conflict of interest: EHC has served on the Scientific Advisory Board for Impel Pharmaceuticals, anticipates research support from Jazz Pharmaceuticals, and receives an editorial stipend from Springer. JVV has consulted or served on advisory boards for Novartis, Roche Pharmaceuticals, and SynapDx; has received research funding from Novartis, Roche Pharmaceuticals, Forest, Seaside Therapeutics, Janssen, SynapDx, Yamo Pharmaceuticals, MapLight, and Acadia; and has received an editorial stipend from Springer and Wiley.

Figures

Figure 1
Figure 1. Comparative maternal, proband, and paternal WB5-HT levels between autism rare variant carriers and noncarriers.
We predicted that the mothers of probands carrying rare autism-associated variants would have lower WB5-HT than mothers of noncarrier probands. With the observation that 5-HT levels in mothers of ASD probands show an upward skew (2), we hypothesized that the mothers of noncarrier probands would not show this skew and would instead show a normal distribution that would largely overlap with the theoretical distribution of the general population (A). Although median maternal WB5-HT did not differ across groups, the distribution was significantly upward shifted in the autism rare-variant noncarriers (B). We observed no significant differences in proband (C) or paternal (D) WB5-HT.
See this image and copyright information in PMC

References

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