Welcome to the Monoamine Oxidase Deficiency Foundation (MAODF) website. This website is dedicated to advancing our understanding of and support for Monoamine Oxidase Deficiency (MAO-D). MAO-D is a rare genetic disorder characterized by impaired activity of the enzymes monoamine oxidase A, B, or both, which are crucial for metabolism of neurotransmitters especially in the brain but also elsewhere in the body. These enzymes are important for the functional regulation of neurotransmitters such as serotonin, dopamine, and norepinephrine in the brain that allow nerve cells to communicate with each other. Thus MAO-D can disrupt the normal functions of neurotransmitters and may result in neurodevelopmental delays, intellectual disability, aggression and autism. Our foundation aims to raise awareness, foster research initiatives, and provide vital resources for individuals and families navigating the complexities of this rare disease.

Here, you’ll discover comprehensive information about MAO-D, updates on ongoing research, personal stories from affected individuals, and opportunities to engage with our supportive community. Together, we strive to empower patients, caregivers and healthcare professionals with knowledge and solidarity in managing this condition.