The NIH is soliciting applications in support of the goals of the Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Initiative and Investigator Consortium. The goal of the PASC Initiative is to rapidly improve understanding of recovery after SARS-CoV-2 infection and to prevent and treat PASC. VUMC investigators have the opportunity to submit to the following programs (see due dates below.) VUMC investigators interested in submitting should send the following to Amy Martinez (amy.f.martinez@vumc.org): one paragraph research description, PI and Co-I names, and ROA number. 

Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: SARS-CoV-2 Recovery Cohort Studies - Research Opportunity Announcement OTA-21-015B, Applications due March 23 

• The SARS-CoV-2 Recovery Cohort is a collaborative meta-cohort that will leverage ongoing and new cohort studies to chart the process of recovery in diverse adult and pediatric populations. This will include cohort studies of patients acutely infected with SARS-CoV-2, cohorts of persons suffering from post-acute symptoms, and appropriate control participants. This ROA focuses on three research study areas: 

• Clinical Recovery Cohort Studies leverage new and existing infrastructure, processes, and data from available cohorts or disease populations to rapidly carry out observational and mechanistic research on the incidence, risk factors, and biologic abnormalities involved in PASC morbidity.   

• Acute and Post-acute SARS-CoV-2 Infection Autopsy Cohort Studies explore the pathology of SARS-CoV-2 infection in those that survived the acute illness. The studies should include recovering adult and/or pediatric patients who had confirmed SARS-CoV-2 infection. 

• EHR- and Other Real-World Data-Based Studies advance the understanding and management of the post-acute sequelae of SARS-CoV-2 infection in both children (including MIS-C) and adults (including pregnant women), by making innovative use of real-world data such as EHRs, health systems data, digital health data, and other large datasets; by further expanding the capabilities of existing data resources toward these ends; and by working in an integrated fashion with other components of the coordinated NIH response to address the post-acute sequelae of SARS-CoV-2.