Chemical and Biomolecular Engineering

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https://ir.vanderbilt.edu/handle/1803/8793
Publications by the Vanderbilt University department of Chemical and Biomolecular Engineering.

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    Delivery of Nanoparticles to Brain Metastases of Breast Cancer Using a Cellular Trojan Horse
    (Springer, 2012-12) Choi, Mi-Ran; Bardhan, Rizia; Stanton-Maxey, Katie; Badve, Sunil; Nakshatri, Harikrishna; Stantz, Keith M.; Cao, Ning; Halas, Naomi J.; Clare, Susan E.
    As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood–brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. Macrophages originating from circulating monocytes are able to infiltrate brain metastases while the BBB is intact. Here, we show that this ability can be exploited to deliver both diagnostic and therapeutic nanoparticles specifically to experimental brain metastases of breast cancer.
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    Composite Electrode Ink Formulation for All Solid-State Batteries
    (Journal of the Electrochemical Society, 2019-09-18) Shen, Fengyu; Dixit, Marm B.; Zaman, Wahid; Hortance, Nicholas; Rogers, Bridget; Hatzell, Kelsey B.
    Solid-state batteries employ composite electrodes which contain a solid ion conductor, a solid active material, a conductive additive, and a binder. The electrode microstructure fundamentally differs from electrodes in conventional batteries because the pore region is ion blocking. While there is extensive research on how to integrate a lithium metal with inorganic electrolytes, there is less knowledge on how an electrode can be integrated with an inorganic electrolyte. Solution processing techniques are ideal for scalable manufacturing and rely on creating an ink which combines the solid material, a binder, and solvent. Ink engineering relies on tailoring the fluidics (rheology), aggregation behavior, and stability for a desired coating process. In this work, we systematically probe the role of two ink constituents: the (1) binder, and (2) solvent on electrode microstructure formation. Lithium titanate anodes achieve nearly a 3-4X increase in capacity from 1.5 mAh/g and 3 mAh/g to 9 mAh/g and >= 12 mAh/g when a high viscosity solvent is employed. The binder plays a larger role in dictating performance of the electrode than surface adhesion properties. Inks with well dispersed constituents led to more effective electrodes for charge storage. (C) The Author(s) 2019. Published by ECS.
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    scRNABatchQC: multi-samples quality control for single cell RNA-seq data
    (Bioinformatics, 2019-12-15) Liu, Qi; Sheng, Quanhu; Ping, Jie; Ramirez, Marisol Adelina; Lau, Ken S.; Coffey, Robert J.; Shyr, Yu
    A Summary: Single cell RNA sequencing is a revolutionary technique to characterize inter-cellular transcriptomics heterogeneity. However, the data are noise-prone because gene expression is often driven by both technical artifacts and genuine biological variations. Proper disentanglement of these two effects is critical to prevent spurious results. While several tools exist to detect and remove low-quality cells in one single cell RNA-seq dataset, there is lack of approach to examining consistency between sample sets and detecting systematic biases, batch effects and outliers. We present scRNABatchQC, an R package to compare multiple sample sets simultaneously over numerous technical and biological features, which gives valuable hints to distinguish technical artifact from biological variations. scRNABatchQC helps identify and systematically characterize sources of variability in single cell transcriptome data. The examination of consistency across datasets allows visual detection of biases and outliers.